Publicaciones

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Evaluation of choroidal thickness in prodromal Alzheimer's disease defined by amyloid PET

Plos One.

To assess and compare the involvement of choroidal thickness (CT) in patients with mild cognitive impairment (MCI) and dementia due to Alzheimer’s disease (AD) defined by amyloid PET and healthy controls (HC).

López-de-Eguileta A, Lage C, López-García S, Pozueta A, García- Martínez M, Kazimierczak M, Bravo M, de Arcocha-Torres M, Banzo I, Jimenez- Bonilla J, Cerveró A, Alexander Goikoetxea, Rodríguez-Rodríguez E, Sánchez- Juan P, Casado A.
Autores

Different follow-up OCT analyses of traumatic optic neuropathy. A case report

Am J Ophthalmol Case Rep

Optical coherence tomography (OCT) is established as a promising technology for assessing the optic nerve atrophy progression after trauma. However, reports on the effectiveness and sensitivity of ganglion cell layer (GCL) and Bruch’s membrane opening-minimum rim width (BMO-MRW) for studying this damage course over time are still lacking.

López-de-Eguileta A, Casado A.
Autores

Retinal vein occlusion in solid organ transplant recipients. Study of 4 cases and literature review

Arch Soc Esp Oftalmol.

Although retinal venous obstruction (RVO) has been primarily related to vascular risk factors and glaucoma, there are a few studies of RVO in patients with solid organ transplants. An analysis was performed on total of 331 patients who presented with RVO (branch RVO in 226 cases and central RVO in 105 cases) over a 10 year period, and the characteristics were compared with the 4 patients with a history of solid organ transplant (liver, renal, or bipulmonary) who presented with RVO. In this series, the onset of RVO in transplant patients occurred at earlier ages than in other patients with RVO (58 vs. 68 years, respectively), affected the central vein of the retina (100% vs. 32%), and was associated with diabetes mellitus (75% vs. 25%), as well as with steroidal (100% vs. 1%) and immunosuppressive (tacrolimus 75% vs. 0%) treatments.

Cerveró A, González Bores P, Casado A, Ruiz Sancho MD, Hernández Hernández JL, Napal Lecumberri JJ.
Autores

Anisocoria as initial manifestation of multiple sclerosis. Use of 3 tesla magnetic resonance imaging

Arch Soc Esp Oftalmol.

A 21-year-old woman seen in this clinic with non-reactive mydriasis in the right eye that contracted with 1% pilocarpine. Cranial angio-CT and 1.5 T magnetic resonance imaging (MRI) did not detect any disease. Given a subsequent limitation of adduction, supraduction, and infarction of the right eye, a 3 T MRI was requested. This showed a lesion of the midbrain at the exit of the 3rd cranial nerve. After improvement, no new episodes were observed until 18 months later, when the patient presented with probable optic neuritis and systemic symptoms. At this time the 1.5 T MRI detected infratentorial and supratentorial demyelinating plaques. A subsequent lumbar puncture and clinic outcome confirmed the diagnosis of relapsing-remitting multiple sclerosis.

Cerveró A, López-de-Eguileta A, Cano-Abascal Á, Sedano-Tous MJ, Drake-Pérez M, Casado A.
Autores

Use of ganglion cell layer analysis for diagnosing anti-glycoprotein neuromyelitis optica of oligodendrocyte myelin

Arch Soc Esp Oftalmol.

The case concerns a 26-year-old patient with bilateral recurrent optic neuritis episodes in the context of suspected neuromyelitis optica. In the first outbreak, she had greatly impaired visual acuity of the left eye, as well as seeing ganglion cell layer damage in both eyes in the optic coherence tomography, with evidence of a possible extensive lesion in the optic chiasma. Likewise, MRI with contrast showed a great involvement of the left optic nerve that compromises the chiasma increasing the suspicion of a neuromyelitis origin. Althogh the anti-myelin oligodendrocyte glycoprotein (MOG) and anti-AQP4 (aquaporin-4) antibodies were negative at first, bilateral involvement of the ganglion cells suggested an extensive lesion that is more characteristic of seropositive anti-MOG neuromyelitis.

Cerveró A, Sedano-Tous MJ, Madera J, López-de-Eguileta A, Casado A.
Autores

Retinal changes in amyotrophic lateral sclerosis: looking at the disease through a new window

J Neurol.

Amyotrophic lateral sclerosis (ALS) is the most frequent degenerative disease affecting motor neurons (MN). ALS has been traditionally considered as a pure motor system disease; however, there are currently sufficient evidences supporting the involvement of other non-motor systems. Recently, the development and the implementation of the optical coherence tomography (OCT) have provided new data regarding the ocular involvement in the disease. In this sense, alterations in retinal nerve fiber layer thickness (RNFL), other retinal layers thicknesses such as outer nuclear layer (ONL) and inner nuclear layer (INL) and changes in the retinal blood vessels have been described in ALS patients. Interestingly, the study of ocular alterations in ALS appears not only as new biomarker tool, but also as a new opportunity to deep into the pathogenesis of the disease. In this article we will review and standardize published studies regarding OCT and ALS, emphasizing both their strengths and weaknesses.

Cerveró A, Casado A, Riancho J.
Autores

Persistent isolated mydriasis as an early sign of internal carotid artery dissection: Pourfour du petit syndrome

Clin Neurol Neurosurg.

The dissection of the internal carotid artery (ICA) is commonly associated with miosis in Bernard-Horner syndrome (BHS). The presence of mydriasis is exceptional but can occur in the context of Pourfour du Petit syndrome (PDPS), a rare entity opposite of BHS accompanied by eyelid retraction and hyperhidrosis and caused by hyperactivity of the sympathetic cervical chain.

Sánchez-de la Torre JR, Drake-Pérez M, Casado A, Palacio-Portilla EJ, Revilla M, Vázquez-Higuera JL, Infante J.
Autores

Peripapillary and macular choroidal thickness before and after phenylephrine instillation

Eye (Lond).

We investigated the effects of topical phenylephrine 2.5% instillation on choroidal thickness (CT), peripapillary choroidal thickness (pCT) and retinal nerve fibre layer (RNFL).

Casado A, López-de-Eguileta A, Gaitán J, Fonseca S, Gordo-Vega MA.
Autores

Topographic correlation and asymmetry analysis of ganglion cell layer thinning and the retinal nerve fiber layer with localized visual field defects

PLoS One.

To evaluate the accuracy of the measurement of the ganglion cell layer (GCL) of the posterior pole analysis (PPA) software of the Spectralis spectral-domain (SD) optical coherence tomography (OCT) device (Heidelberg Engineering, Inc., Heidelberg, Germany), the asymmetry of paired GCL sectors, the total retinal thickness asymmetry (RTA), and the peripapillary retinal nerve fiber layer (pRNFL) test to discriminate between healthy, early and advanced glaucoma eyes.

Casado A, Cerveró A, López-de-Eguileta A, Fernández R, Fonseca S, González JC, Pacheco G, Gándara E, Gordo-Vega MÁ.
Autores

Ganglion cell layer thinning in prodromal Alzheimer's disease defined by amyloid PET

Alzheimers Dement (N Y).

The objective of this study was to investigate and compare optic nerve and retinal layers in eyes of patients with mild cognitive impairment (MCI) and Alzheimer’s disease (AD) with paired control eyes using optical coherence tomography.

López-de-Eguileta A, Lage C, López-García S, Pozueta A, García-Martínez M, Kazimierczak M, Bravo M, de Arcocha-Torres M, Banzo I, Jimenez-Bonilla J, Cerveró A, Rodríguez-Rodríguez E, Sánchez-Juan P, Casado A.
Autores

Hyperbaric oxygen therapy in the treatment of central retinal artery occlusion

EMERGENCIAS.

Oxigenoterapia hiperbárica en el tratamiento de la oclusión de la arteria central de la retina

López-de-Eguileta A, Lage C, López-García S, Pozueta A, García-Martínez M, Kazimierczak M, Bravo M, de Arcocha-Torres M, Banzo I, Jimenez-Bonilla J, Cerveró A, Rodríguez-Rodríguez E, Sánchez-Juan P, Casado A.
Autores

Diagnosing and Managing a Case with a Fourth Nerve Palsy and Papilledema

CRIMSON PUBLISHERS

A 14-year-old boy presented to the Hospital with new-onset vertical binocular diplopia. Medical history was notable for a recent cranial traumatism. On examination, visual acuity was 20/20 in
each eye. Pupils were equal and reactive.

Hac click en más información para continuar leyendo el caso.

Fernández-Menéndez A, Casado A.
Autores

Results in Superior Oblique Sharpening in Brown Syndrome and Systemic Pediatric Diseases

sCIENCEPG

The objective of this study was to evaluate and compare epidemiological factors, associated diseases, exploration and outcomes in patients with Brown Syndrome (BS) operated of superior oblique (SO) sharpening. This is a cross-sectional comparative study. 24 patients with BS operated of SO sharpening were enrolled in this study. The adduction-elevation restriction (AER), torticollis, visual acuity, treatments, trochlea triamcinolone-injections, age of surgery and systemic diseases were assessed. Fisher’s test was used to analyze if there is any association between the variables analyzed with systemic diseases. Differences between preoperative and postoperative status were analyzed using the Wilcoxon test with Bonferroni correction post hoc. We found a preoperative mean AER (0-3) was 2.88. One year after the surgery, mean AER it was 0.59 (P<0.001). Preoperative torticollis was observed in 79.1% patients. Torticollis was solved in 95.8% of cases in one year follow-up (P<0.001). Most common concomitant diseases were allergic asthma (12.5%), adenoid hypertrophy (12.5%), and heart murmurs (12.5%). No significant association of systemic disease with postsurgical torticollis or AER was found (P>0.05). In conclusion, SO sharpening constitutes a safe and effective surgery for BS, with fewer complications than other techniques previously described. Hac click en más información para continuar leyendo el caso.

Fernández-Menéndez A, Casado A, Rodríguez JM.
Autores

Differences in Corneal Biomechanics in Nonpenetrating Deep Sclerectomy and Deep Sclerectomy Reconverted into Trabeculectomy

PMC.

To investigate and compare the false-positive (FP) diagnostic classification of the Bruch’s membrane opening – minimum rim width (BMO-MRW) and retinal nerve fiber layer (RNFL) thickness in healthy eyes with tilted optic disc.

Rebolleda G, Casado A, Oblanca N, Muñoz-Negrete FJ.
Autores

The new Bruch’s membrane opening – minimum rim width classification improves optical coherence tomography specificity in tilted discs

J Glaucoma.

To evaluate the differences in intraocular pressure (IOP) and in corneal biomechanics in eyes with uneventful nonpenetrating deep sclerectomy (NPDS) in 1 eye and with intended deep sclerectomy reconverted into trabeculectomy (RIT) in the fellow eye of the same patient.

Casado A, Cabarga C, Pérez-Sarriegui A, Fuentemilla E.
Autores

Optic Nerve Head Biomechanic and IOP Changes Before and After the Injection of Aflibercept for Neovascular Age-Related Macular Degeneration

Invest Ophthalmol Vis Sci.

We investigated the early effects of intravitreal aflibercept injection (IAI) on optic nerve head (ONH) morphology.

Rebolleda G, Puerto B, de Juan V, Gómez-Mariscal M, Muñoz-Negrete FJ, Casado A.
Autores

Dexamethasone implant removal from anterior chamber. Surgical technique

Retin Cases Brief Rep.

To describe a surgical technique for complete and safe dexamethasone intravitreal implant (Ozurdex; Allergan, Inc., Irvine, CA) removal from anterior chamber.

Ruiz-Casas D, Gros-Otero J,Casado A.
Autores

Impact of Introducing 2 Simple Technique Modifications on the Descemet Membrane Endothelial Keratoplasty Learning Curve

European journal of opthalmology

To analyze the impact of performing premarking of the Descemet roll and using SF6 20% on a surgeon’s Descemet membrane endothelial keratoplasty (DMEK) learning process.

Arnalich-Montiel F, Pérez-Sarriegui A, Casado A.
Autores

The Disreputable History of Case Reports in Ophthalmology

sm journal of case reports

Only authors know how tough is today to publish an interest case report in ophthalmology. Even the case is not previously described and for sure its publication will help other clinicians to better treat their patients, many submitted case reports are rejected quickly by most clinical journals.

Casado A.
Autores

Retinal Primary Benign Tumor with Unusual Histopathological Exam

Aperito Journal of Ophthalmology

To describe a new subtype of retinal tumor. Conclusion: To the authors’ knowledge, we report a case of benign retinal tumor not previously described, that seemed a vasoproliferative tumor but with unusual histopathological markers.

Alfonso Casado, María Moreno, Ana Albandea, Ane Pérez-Sarriegui, Pernilla S Tirad
Autores

Nonpenetrating deep sclerectomy for glaucoma after descemet stripping automated endothelial keratoplasty: three consecutive case reports

Medicine (Baltimore).

The purpose of this study was to evaluate the efficacy and safety of nonpenetrating deep sclerectomy (NPDS) in 3 consecutive eyes with preexisting and uncontrolled glaucoma after Descemet stripping with automated endothelial keratoplasty (DSAEK).NPDS with intrascleral implant and topical adjunctive intraoperative mitomycin C (0.2 mg/mL 1 minute) was performed.Intraocular pressure (IOP) and number of glaucoma medication were registered before and after NPDS with at least 1-year follow-up. Intraoperative and postoperative complications were also registered.Before NPDS, IOP was 18 mm Hg in 1 patient and 32 mm Hg in the other 2 patients. Four antiglaucoma drugs were used in 2 cases and 3 in the other one. At 1 year after NPDS, all the patients had an IOP ≤18 mm Hg. Two patients required postoperative antiglaucoma medications (1 drug in 1 case and 2 drugs in the other one). Neodymium-doped yttrium aluminum garnet laser goniopuncture was needed in 2 patients and it had to be repeated in 1 of them. No complications related to NPDS were observed. A corneal graft rejection was observed 5 months after NPDS in 1 case that resolved without sequelae with intensive corticosteroid eye-drop therapy.NPDS could be a safe and successful alternative to conventional filtration surgery after DSAEK in eyes with uncontrolled glaucoma. Larger series and a longer follow-up would be necessary to set the actual role of surgery in DSAEK patients.

Muñoz-Negrete FJ, Arnalich-Montiel F, Casado A, Rebolleda G.
Autores

OCT: New perspectives in neuro-ophthalmology

Saudi J Ophthalmol.

Optical coherence tomography (OCT) has become essential to evaluate axonal/neuronal integrity, to assess disease progression in the afferent visual pathway and to predict visual recovery after surgery in compressive optic neuropathies. Besides that OCT testing is considered a powerful biomarker of neurodegeneration and a promising outcome measure for neuroprotective trials in multiple sclerosis (MS). Currently, spectral-domain OCT (SD-OCT) technology allows quantification of retinal individual layers. The Ganglion Cell layer (GCL) investigation has become one of the most useful tools from a neuro-ophthalmic perspective. It has a high correlation with perimetry, is predictive of future progression and is a highly sensitive, specific of several neuro-ophthalmic pathologies. Moreover the superior correlation with clinical measures compared to peripapillary retinal nerve fiber layer (pRNFL) suggests that GCL analysis might be a better approach to examine MS neurodegeneration. In disorders with optic disk edema, such as ischemic optic neuropathy, papillitis and papilledema, reduction in RNFL thickness caused by axonal atrophy is difficult to distinguish from a swelling resolution. In this setting, and in buried optic nerve head drusen (ONHD), GCL analysis may provide more accurate information than RNFL analysis and it might be an early structural indicator of irreversible neuronal loss. Enhanced depth imaging OCT (EDI-OCT) provides in vivo detail of ONHD, allowing to evaluate and quantify the drusen dimensions. OCT is improving our knowledge in hereditary optic neuropathies. Furthermore, there is growing evidence about the role of OCT as an adjunctive biomarker of disorders such as Alzheimer and Parkinson’s disease.

Rebolleda G, Diez-Alvarez L, Casado A, Sánchez-Sánchez C1, de Dompablo E, González-López JJ, Muñoz-Negrete FJ.
Autores

Adipose-Derived Mesenchymal Stem Cell Administration Does Not Improve Corneal Graft Survival Outcome

plos one.

The effect of local and systemic injections of mesenchymal stem cells derived from adipose tissue (AD-MSC) into rabbit models of corneal allograft rejection with either normal-risk or high-risk vascularized corneal beds was investigated. The models we present in this study are more similar to human corneal transplants than previously reported murine models. Our aim was to prevent transplant rejection and increase the length of graft survival. In the normal-risk transplant model, in contrast to our expectations, the injection of AD-MSC into the graft junction during surgery resulted in the induction of increased signs of inflammation such as corneal edema with increased thickness, and a higher level of infiltration of leukocytes. This process led to a lower survival of the graft compared with the sham-treated corneal transplants. In the high-risk transplant model, in which immune ocular privilege was undermined by the induction of neovascularization prior to graft surgery, we found the use of systemic rabbit AD-MSCs prior to surgery, during surgery, and at various time points after surgery resulted in a shorter survival of the graft compared with the non-treated corneal grafts. Based on our results, local or systemic treatment with AD-MSCs to prevent corneal rejection in rabbit corneal models at normal or high risk of rejection does not increase survival but rather can increase inflammation and neovascularization and break the innate ocular immune privilege. This result can be partially explained by the immunomarkers, lack of immunosuppressive ability and immunophenotypical secretion molecules characterization of AD-MSC used in this study. Parameters including the risk of rejection, the inflammatory/vascularization environment, the cell source, the time of injection, the immunosuppression, the number of cells, and the mode of delivery must be established before translating the possible benefits of the use of MSCs in corneal transplants to clinical practice.

Fuentes-Julián S, Arnalich-Montiel F, Jaumandreu L, Leal M, Casado A, García-Tuñon I, Hernández-Jiménez E, López-Collazo E, De Miguel MP.
Autores

Measurement of retinal nerve fiber layer and macular ganglion cell-inner plexiform layer with spectral-domain optical coherence tomography in patients with optic nerve head drusen

Graefes Arch Clin Exp Ophthalmol.

To evaluate the effect of optic nerve head drusen (ONHD) on the retinal nerve fiber layer (RNFL) and macular ganglion cell-inner plexiform layer (GCIPL) using Cirrus optical coherence tomography (OCT).

Casado A, Rebolleda G, Guerrero L, Leal M, Contreras I, Oblanca N, Muñoz-Negrete FJ.
Autores

Suspected granulomatous anterior uveitis associated with brimonidine tartrate 0.2% and timolol maleate 0.5% ophthalmic solution

Graefes Arch Clin Exp Ophthalmol.

Casado A, Cabarga C, de la Fuente MA, Muñoz-Negrete FJ.
Autores